Challenges of electrophoretic mobility measurements

<p><a class="wikilink" href="/electrophoretic_mobility/">electrophoretic mobility</a> is commonly studied in ensemble, which has an inherent limitation by averaging out processes which can be very diverse from particle to particle. Therefore, studying single-particle electrophoresis may open the door to intriguing new results. </p> <p>At the single-particle level, measuring electrophoretic mobility requires:</p> <ul> <li>Tracking the motion of particles with sufficient spatial and temporal resolution</li> </ul> <p>This is where optical methods may be of help (<a class="litnote tooltip" href="/literature/@faez2016">@faez2016<span class="tooltiptext">Nanocapillary electrokinetic tracking for monitoring charge fluctuations on a single nanoparticle</span></a>). Especially, one can do <a class="wikilink" href="/nanoparticle_tracking_in_hollow_optical_fibers/">nanoparticle tracking in hollow optical fibers</a>, which has the advantage of both high-localization accuracy (sub-wavelength) and high frame-rates[<a class="litnote tooltip" href="/literature/@faez2015">@faez2015<span class="tooltiptext">Fast, Label-Free Tracking of Single Viruses and Weakly Scattering Nanoparticles in a Nanofluidic Optical Fiber</span></a>]. </p> <p>See: <a class="wikilink" href="/nanocet_implementation/">nanoCET implementation</a></p>