Challenges of electrophoretic mobility measurements

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electrophoretic mobility is commonly studied in ensemble, which has an inherent limitation by averaging out processes which can be very diverse from particle to particle. Therefore, studying single-particle electrophoresis may open the door to intriguing new results.

At the single-particle level, measuring electrophoretic mobility requires:

  • Tracking the motion of particles with sufficient spatial and temporal resolution

This is where optical methods may be of help (@faez2016Nanocapillary electrokinetic tracking for monitoring charge fluctuations on a single nanoparticle). Especially, one can do nanoparticle tracking in hollow optical fibers, which has the advantage of both high-localization accuracy (sub-wavelength) and high frame-rates[@faez2015Fast, Label-Free Tracking of Single Viruses and Weakly Scattering Nanoparticles in a Nanofluidic Optical Fiber].

See: nanoCET implementation


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Aquiles Carattino
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