Literature/202310112003 acoustic force spectroscopy for single-molecule applications

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The idea of acoustic force spectroscopy relies on a relatively simple principle of Acoustic trapping. A standing pressure wave is created in a medium and particles will go towards the nodes. Particularly, in the setup described (figure below) the standing wave creates a planar structure, and therefore the trap only acts in 1-D.

images/Pasted image 20231012135717.pngThe immediate idea is to use the setup to perform parallel measurements of trapped beads linked to the surface via a dsDNA molecule. The results are as expected (nothing particularly new, just a proof of principle)

images/Pasted image 20231012140038.png

And to show the parallelization capabilities, the authors create a series of histograms of distribution of rupture forces, but importantly, they show an example of how their data looks like:

images/Pasted image 20231012140332.png

Lumicks commercializes this technology under the name of z-movi.


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Aquiles Carattino
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