Good reasons for targeting SARS-CoV-2 by engineered extracellular vesicles
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SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor
ACE2. Engineered extracellular vesicles (EVs) exposing specific antibody fragments,
namely nanobodies, are efficient decoys for S protein. EVs may act as a multifunctional
vector to reduce SARS-CoV-2 infectivity and simultaneously modulate the inflammatory
microenvironment in COVID-19 patients.
</p>
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