Good reasons for targeting SARS-CoV-2 by engineered extracellular vesicles
Literature Reference
Authors:
Ario de Marco, Lucio Barile
Year: 2022
SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2. Engineered extracellular vesicles (EVs) exposing specific antibody fragments, namely nanobodies, are efficient decoys for S protein. EVs may act as a multifunctional vector to reduce SARS-CoV-2 infectivity and simultaneously modulate the inflammatory microenvironment in COVID-19 patients.
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