Comment on “Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines”
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I read with surprise that Bansel et al. ([1][1]) detected the exosomal spike protein (S2) of SARS-CoV-2 in the vaccinee's plasma 4 mo after vaccination of BNT162b2. There are notable caveats in their analysis; first, the authors used the precipitation-based commercial kit for the exosome isolation,
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