Interferometric Scattering (iSCAT) Microscopy and Related Techniques

<!-- START_ABSTRACT --> <p> Interferometric scattering (iSCAT) microscopyMicroscopyinterferometric scattering (iSCAT) is aScatteringinterferometric powerful tool for label-freeLabel-free sensitive detection and imaging of nanoparticlesNanoparticle to highResolutionspatio-temporal spatiotemporal resolutionResolutiontemporal. As it was born out of detection principlesPrinciples central to conventional microscopy, we begin by surveying the historicalHistorical development of the microscope to examine how the exciting possibility for interferometric scattering microscopyMicroscopyinterferometric scattering (iSCAT) with sensitivities sufficient to observe singleSingle molecule moleculesMicroscopysingle-molecule localization has become a reality. We discuss the theory of interferometric detection and also issues relevant to achieving a high detection sensitivitySensitivity and speed. A showcase of numerous applications and avenues of novel research across various disciplines that iSCAT microscopy has opened up is also presented. </p> <!-- END_ABSTRACT --> <!-- START_TEMPLATE --> <ul> <li> Source: </li> <li> Tags: </li> </ul> <!-- END_TEMPLATE -->