Hiv-1 contains cd9 and cd63

<p>Although <a class="wikilink" href="/cd9/">CD9</a> and <a class="wikilink" href="/cd63/">CD63</a> are used to detect <a class="wikilink" href="/extracellular_vesicles/">extracellular vesicles</a>, they are also present in viruses that use outward budding from host cell membrane to form their envelope[@duijvesz2015a]. Such is the case of the <a class="wikilink" href="/hiv/">HIV</a>-1 virus. </p> <p>During the infection, there can be a change in the small <a class="wikilink" href="/ev/">EV</a> composition[<a class="litnote tooltip" href="/literature/@martinjaular2021">@martinjaular2021<span class="tooltiptext">Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection</span></a>], but the most important challenge is that the nascent viral particle is similar to EV composition, size, and physical features. Therefore <a class="wikilink" href="/it_is_challenging_to_distinguish_hiv_viruses_from_evs/">it is challenging to distinguish HIV viruses from EVs</a>. </p> <p>One path forward could be to perform a <a class="wikilink" href="/proteomeic_profile_of_evs/">proteomeic profile of EVs</a> in order to study difference at a protein level.</p>