The status quo of the research industry

This is what [@ioannidis2014How to Make More Published Research True] describes as the status quo of the research industry:

• Research is an industry with over 15M people authoring papers (25M were published between 1996 and 2011)
• Results and applications are exaggerated, translation (i.e. technology transfer) is slow and inefficient
• 85% of research resources are wasted (#TODO: check reference # 5)
• Non-meritocratic practices like nepotism, sexism, unwarranted conservatism are probably widespread
• There is little experimental evidence on how peer review should be done and when (protocol-based, manuscript-based, post-publication)
• Scientific structures can be traced back to the Middle Ages (academic hierarchies) or the 17th century: professional societies, journal publishing. Is this still valid today?