Low abundance evs

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In the context where every cell (and even organelles) can create extracellular vesicles that are then released to the environment, detecting very low abundance species can be the only way to use them as diagnostic markers (see Extracellular vesicles as markers for prostate cancer, EVs can be used as ovarian cancer markers using EVs as biomarkers)

Some strategies focus on enrichment of specific subpopulations based on physicochemical traits (for example see: Size exclusion chromatography is the second most popular EV enrichment method and Ultra centrifugations is the most popular EV enrichment method).

Besides enrichment, readout systems that have high-throughput and the ability to detect single-events can be a valuable tool to use EVs as biomarkers. See, for example: literature/202301141333 Comparing SiMoA and SP-IRIS.

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Notes should be concept-based
Public engagement with research activities
Novelty is not Innovation
Tango in Times of Corona
Why we teach science in school
Essays/linkedin/24-05-15 marketing for scipreneurs
The effect of the track length on the accuracy of the diffusion coefficient in MSD measurements
Hydrogels can encapsulate live cells
Literature/@pedrioli2021
Limitations of flow cytometry
How to Make Cool Underlines for Links with TailwindCSS
Gardening in public
Comparing facebook revenue with country budgets
City planning with biased data
Literature/202301241150 different modes of operation of microfluidic free-flow electrophoresis
Genetic studies reveal relationship between different homo species
Education allows upwards social mobility
Spectradyne
Mental Model
Executives are not effectual reasoners
Reversing Science Education
Arctoris Lab Automation
Scientific products
Literature/open-source miniature spectrophotometer (osms)
Founders have a fundamental role in customer discovery
Marketing blogs are not meant to be a digital garden
Gender neutral infrastructure favors men
My Wedding App
Non-egalitarian groups reside with fewer unrelated individuals
Philips Monitors Make an Annoying Sound
Extracellular vesicles as markers for prostate cancer
Measuring size of evs with confocal microscopy
Klimaat helpdesk
How can links replace the ordering of notes in a box
Eccentric scientist type
Let the other person feel that the idea is his or hers
Men overestimate their smartness
Kano model
Technology readiness level
How much unpaid work is done by women
Unpaid work done by women
Ultra centrifugation
Everyone can Build a Twitter Audience
Mendeley
Aquiles Carattino Open Notes
Scipreneurs need someone with whom to build
Fundamental Attribution Error
How to write a good cover letter for a job
Tasks to write efficiently
Cartesian dualism
Product development
Throw down a challenge
Python for the Lab
Venture capitalists
Dewey decimal classification
Essays/linkedin/23-12-13 trust for startups
Stimulated raman emission
Building complexity by linking articles
Sp-iris
Violencia, boliches, rugby y las cosas que nadie discute
Scientific exploration and play
How to write a programming book
Sócrates estaba en contra de los libros
Proton Mail takes a Stance Against Apple Practices
Digital gardens for content creation
Problem recognition
Luhmann notes are static
Deep tech
scipreneurs #scientists-entrepreneurs #equity
Effect of temperature on determination of error in diffusion measurements
Scientist are changing how they consume content
Spin sales
Early progress is not a persistent indicator
Building reputation
Citizen science
Exoview
Brownian Diffusion
Personal data collection, what is it and where it starts
Dispertech
Essays/linkedin/24-01-25 kings or rich
Being Wrong in Public
Patents and Research
Evs and viruses are similar
Product market fit for scientific instrumentation
Ciencia ciudadana
failing #startups #entrepreneurs
RSS Feeds in Digital Gardens
Essays/how it feels quitting your own startup
Product lifecycle
Patents can be used to block third parties
Catalytic experience of invitae
The problem with people in positions of power in academia
Tech Notes
Bias towards men problems means less research focused on women health
What are patents for
Post hoc ergo propter hoc
Bikepacking trip through Belgium
The sociology of lockdowns
Carbon Cycle
Negative 2000 lines of code
Sec
Calculating diffusion coefficient from jump statistics
Luhmann method
Value proposition-market fit
The 3-month scipreneurial path
Essays/linkedin/24-01-11 build tony fadell
Simoa
Open Source is not what it was
Designing tools for work is traditionally done considering the *average* man and not woman
The Eleventh Commandment - Jeffrey Archer
Parsing tags in markdown
Education content for sales
Bayh-dole act to favor commercialization of university technology
Correlating gdp to scientific productivity is a reasonable proxy for progress
Social mobility
Literature/202304141541 diversity efforts that work
Essays/linkedin/ crossing boundaries
Sobre Aquiles Carattino
Company building
Categories of competitors
The Passion Economy
Technolgy transfer
Circulating tumor cells
Value-based selling
Technology push
Citizen science can create a more participative democracy
El tango de la guardia vieja - arturo pérez-reverte
Humoral immunity
Ultra centrifugations is the most popular ev enrichment method
Reforestation
Dramatize your ideas
Hplc
Role of regulatory bodies in the gender data gap
Basic competences that define scientific literacy
University students perform poorly in basic science tests
Social networks exploit the reward equation
Why footnotes should be side notes on websites
Scientific instruments
We are Craving for Data
Tyranny of the langmuir binding isotherm
Science-based startups
Changing scientific incentives can help overcome stagnation
Quantitative performance measurements produce undesired outputs
Since most startups fail, there's a large number of false positive observations
Calculating the gdp of a country should include the unpaid work done by women
A Healthier Internet
Patents
Open science
Why keeping a lab journal
Overload of information is pushing us to spaces with restricted access
Optimal number of fitting points for msd measurements
Risk
Zotero
Social media for scientific marketing
Overkill hypothesis
The Economy of Open Source Software
Advise
Science only works in the Class Room
Limits of time-based separation methods
Siloing of Information
Why improving the science teaching
Prostate cancer
Patents and spin-offs do not have the same added value
Taking notes for knowledge creation
Subscription-Based Product
Startups are not scaled down versions of companies
Switching contexts has a cost
Limitations to A4F-DLS-MALS
Scipreneurs/book/00 index
Effectual bird in the hand
Neanderthal dna deserts
Molecular shot noise
Nanoscale deterministic lateral-displacement pillar arrays
Essays/linkedin/24-05-13 startup studio for deep tech
Essays/linkedin/24-04-30 too busy for your team
Literature/202111292230 diesel is the most efficient energy storage solution for transport
202304011243
My public keys
Talk to Me
Motivations for entrepreneurs
Project hail mary - andy weir
Nanoview biosciences
The traditional marketing funnel
Essays/linkedin/ reality
Mtt
Flux biosciences
Identifying the biggest solutions
Measuring
Essays/linkedin/24-05-17 label free
Literature/@gentner2023
Exosomes
Literature/202405110829 cytometer to measure full empty ratio of lnp
Limitations of fluorescence labeling for quantification
Essays/linkedin/24-05-06 six sigma
Literature/202405081109 patents in research institutions
The role of a distributor
Literature/202301141333 comparing simoa and sp-iris
Market requests for a technology
Essays/linkedin/24-05-28 average advice
Expansion microscopy
Literature/202306121207 using open-hardware to bypass ttos
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How the scientific mind works
Things i try to increase diversity
Developing an Entrepreneurial Mindset
Trps
Gross margins
Machine learning
Launching and Scaling Your Startup: Strategies for Growth and Sustainability
Money incentives to build a community
NSM
Literature/202212281528 refractive index measurement of evs with inta
Measuring performance using single criteria
Essays/linkedin/ brainstorming
Hermeneutic circle
Technology Transfer
High value ideas are based on research and science
Modeling Data as a Scarce Resource
Maternity leave
Making Myself Available for a Talk
Entrepreneurial Mindset for Scientists
Process of Automatizing
Literature/@rieu2021
Innovation led policies
Literature/202306121138 different types of open hardware
Male by default
Determining drug loading and release kinetics in nanoparticles
Imaging flow cytometer
Substack
Essays/linkedin/ open innovation
My Writing Habits
Literature/202101311220 a new ontology to understand inca cosmology
Tr-fia
Literature/@scotte2020
Gender Unbalance
Literature/202311221425 - skills to become a scientist entrepreneur
Literature/202405081203 open-source model for patents
Make the other person feel important - and do it sincerely
Essays/linkedin/24-03-28 outside the box
What Is a Blogchain?
Technological progress is slower than Moore’s law predicts
Essays/linkedin/24-02-06 misconception 2 equity split
Open hardware microscope chambers
Cogs
Even if correlation is not causation
Playbook Entrepreneurship for Academics
Teachers lack tools to design a science curriculum
Columbus could have used a wrong estimate of earth's diameter
Sales roadmap
202206290743
Astroplant
Essays/linkedin/24-04-24 capital costs deep tech
Why doing a phd
innovation #productdevelopment #productmarketfit
Open hardware
Piloting a new venture
Operación Kazán - Vicente Vallés
Bullet journaling
Composite measures of performance
Why companies fund open source software
scipreneurs #startups #innovation #scientists-entrepreneurs
Essays/linkedin/ overvalue gray hair
Improved methods for fluorescent labeling and detection of single extracellular vesicles using nanoparticle tracking analysis
Mentorship is an invaluable asset for starting entrepreneurs.
Determining the best number of fitting points for MSD data
Online version of Python for the Lab
Retrieval and storage strength
Notes on Working in Public - Nadia Eghbal
Nta
Digital gardens and personal blogs
RSS Feed
We think future is something that happens to us
La Inevitabilidad de Envejecer
Essays/linkedin/23-12-05 co founders
Essays/linkedin/24-01-10 ai for everything
Replacing analysis with statistics
Role Models
Choosing between Zettlr and Obsidian
Design thinking for business models
Reproducibility is the key factor of open science
Restrictions can help the creative process
Content centric model of marketing
Balliamo - Orquesta Típica Andariega
Uncover the desire
Syntenin-1
scipreneurs #productmarketfit #customeroriented
Intellectual Property and Protecting Your Innovations
Calculating diffusion coefficient from mean squared displacement data
Formatting strings in two steps with Python
Una extinción dentro nuestro
Essays/linkedin/24-01-09 making it cheaper
Washburn's Equation
Hollow core fibers can increase the throughput of analyzed particles
Open innovation
Las máquinas no pueden soñar
Limit the number of male speakers in conferences
Resegmented existing market positioning
Literature/202410012120 product vision
Me-lead vc firms are biased towards favoring men-specific problems
The Price of the Amazon Rainforest
Aquiles.me newsletter
Minimum viable prototype
If a person is exposed to a figure for 500ms they'll be able to remember some features and draw conclusions
Scipreneurs/7-day-intro/2 - find out what you do
Now
Iscat
Single-molecule detection with a 3d printed microscope
Free flow electrophoresis
Mass spectrometry
Literature/@kim2015
How to extract ev's from blood plasma
Hype curve
Embracing the Scipreneur Mindset: Transitioning from Scientist to Entrepreneur
Net margins
Hollow optical fibers
Nanoparticles
Market type
Mbfcm
Epitope
Epistemic Status
Flow cytometer
Literature/202311280851 tracking charges in lithium electrodes
Illumion
Hollow optical fiber
Extending USB cable with Amphenol connector
The status quo of the research industry
I don't think blogs broke the internet
How Technology can Shape Education
Locating particles for nanoparticle tracking
I deleted my Facebook account
Knowledge spill-over
202405221743
Inca Cosmology
Hollow core fibers
Let the other person do a great deal of the talking
Technology not addressing a problem
Nanosight proprietary software update
202304271736
The three worlds of the andean cosmos
Bioenergy with Carbon Capture and Storage
Startup studio
How phillips protected ip by not outsourcing key manufacturing components
Adding a .env file to vscode so it finds our python module
The Community Around Open Source
Random forest particle classifier
Levels of awareness for marketing
Zettelkasten method
Democracy and algorithms
Epigenetics
Cumulative culture
Functional or Imperative Programming
Inflation
Risks and opportunities of open-source are misjudged
There is a discrepancy in the reported concentration between nta and evquant
Citizen science in schools
Sales are based on trust
It's a pity that RSS feeds are fading away
Challenges for the use of hydrogels in medicine
Data collection
Scrum development
Facebook Can't Regulate Itself
Isoelectric focusing
Differential schemes for particle detection
Hiring based on talent
Bomboncito de Napalm
Extracellular vesicles
Love the problem if you don't know what it is
Effectuation theory for entrepreneurs
Inta
Build trust in a team
Establishing thresholds for idea validation
Sporozoites
Essays/linkedin/ startup team
Habits are persistent
Izon
Images/screenshot
scipreneurs #entrepreneurs #startups #superlineargrowth
Los romanos adoptaron la cultura griega
We Missed the Opportunity to Make the Right Choice and Build a Better Internet
Jobs theory around scientific products
Essays/linkedin/ misconception 6 de risking
Dark forest theory
Classification systems are crucial for a language survival
The role of search engines for scientific marketing
Myriade
Essays/ splitting shares of a startup should reflect future work
Become genuinely interested in other people
Dark, german TV Show
Customer discovery
Risks in starting a scientific company
Develop a combination of methods to measure particle size distribution of medical nanoparticles
Gray hair fallacy
Slow Horses - Mick Herron
First-mover advantage
Crazy quilt around a product
Literature/@bloom2020
The interaction between Stackoverflow and Github
Common problems with open source projects
The power of flow cytometry
Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
Pricing products
Freeing short term memory
Coulter counter
Essays/linkedin/ misconception 7 you need a ceo
Customer validation
Reactivating past customers
shinrin-yoku
Ccmv virions
Selling open-hardware tools
Be a good listener. encourage others to talk about themselves
La forma de leer cambió en el tiempo
Public engagement with research is challenging
Women are half the population, not a minority
The five different types of attention when doing creative work
Difference conda environment and virtual environment in pyhon
Is openspim a good example of open hardware
Image restoration for nanoparticle tracking
Poisson sampling
Business model canvas
To pay or not to pay reviewers of scientific papers
Mbti personality indicator
Grant recipients are ageing
Literature/202311280955 socialize risks and privatize rewards
Job titles can stunt startup development
Essays/linkedin/23-12-11 science needs entrepreneurship
Gender diversity in tech
Multiplex bead-based flow cytometry
3r principle
Get Time of First Commit of a File
Stokes-einstein relationship
Disadvantage of hollow optical fibers for exciting particles
Digital Garden
Digital garden
Time-based separation methods
Venture capital is more short-termist than what research needs
Correletion between time spent and competency in scientific literacy
Literature/202311111404 staying warm and cool
Essays/the things i miss the most from my time as a phd
Essays/linkedin/23-12-06 working hard
Calibration services for open-hardware tools
Essays/linkedin/23-11-16 male deep tech

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