Why pushing sensitivity of assays

First published:

Last Edited:

Number of edits:

Normal assays for biomolecules have detection thresholds of around $pM$. However, a tumor of $1mm^3$ contains around 1 million cells. Each secrete around 5000 proteins, and the human body has around 5 liters of blood. This gives around:

$$10^6 \frac{\textrm{prot}}{ml}$$, or

$$2\cdot10^{-15}\textrm{M}$$

Backlinks

These are the other notes that link to this one.

Patent fight around CRISPR technologies
Terrarium closed for 50 years is life's microcosm
Literature/202212281435 polydisperse samples with inta
Literature/@mazurczyk2006
Literature/202305251750 open hardware can transform access to lab equipment
Essays/linkedin/24-02-14 starting is hard
Scipreneurs/7-day-intro/1 - know yourself
Continuity of design is required by persistent users
ProtonVPN at startup on Linux
Literature/@merryweather2021
Essays/linkedin/ scientists ingest vast amounts of information
Literature/@mazurczyk2008
Agriculture created new social hierarchies
Developing Your First Product: From Concept to Prototype
Digital learning tools based on the luhman method
Effectual Reasoning
git as a commenting platform
Essays/linkedin/24-04-29 open hardware
Literature/202405081136 law regarding research use exemptions
Literature/@iso 18069 2015
Images/tetraspanin
Literature/@khan2023
Images/pasted
Essays/linkedin/24-05-20 from science to technology
Citations make science conservative
Resonance calendar/ init .py files are optional
Circulating tumor cells for prostate cancer diagnosis
Essays/linkedin/24-05-07 sales are never short
Diversity in startups is challenging
Python Config Parser
Eratosthenes was the director of the great library of alexandria
Things I've Done
Frugal science
Using evs as biomarkers
Microvesicles
Essays/how to incentivize a scipreneurial path
Nascent ventures
External analysis for new ventures
Technical Inequality
mvp #hardware #scipreneurs #techtransfer
Focus on one target market or persona at a time
Literature/202405081103 research exemption for patented knowledge
Flamingo project
Pleistocene extinctions
Essays/linkedin/ signature
Arouse in the other person an eager want
Appeal to the nobler motives
Essays/linkedin/24-05-02 don't trust my advice
Evergreen marketing
Ella la Cazadora
Escrt
Things that can scale
La llegada de la Sputnik V a Argentina
Revert to the Last Known Working State
Essays/linkedin/24-04-25 never stop learning
Review of PyAstroPol
My cv made into a podcast
Essays/linkedin/24-01-31 writing more
Miss out opportunities because of internal culture
El Problema de los Tres Cuerpos - Liu Cixin
Sampling error when measuring the average diffusion coefficient
Essays/linkedin/24-05-09 hardware mvp
Essays/do things that can scale
Literature/@elsharkasy2020
Literature/202301192057 free flow electrophoresis
Hemozoin
Educational tools based on the ideas of spaced repetition
Analog versus digital detection of molecules
I don't Click on Newsletter Links Because I Know they Track me
Literature/202311101914 the problem with electricy
Chrome will phase out third party cookies
Choosing pycharm over vscode
The golden circle
Essays/linkedin/24-04-20 humane ai
Changing habits with sliding temporal windows
Jobs theory and customer journeys
Cuantificar lo que no sabemos
Patents should not be an obstacle for innovation
The world in 2050 if we don't stop the heating
Jobs theory
Literature/202301141616 membrane-binding peptides to detect small evs
How to backup my data
Customer creation
Scipreneurs will greatly benefit from it: you'll be able to move beyond the "problem-solution" framework, and it gives the tools to understanding complex contexts, the competition, and how to develop a compelling value proposition.
Patents can be awarded to ideas without empiric verification
The Future We Choose
The zombie stat
Mi Rincón en Internet
Arctoris CV Suggestions
Choosing technology based on their incentives
Essays/exciting vesicles - the field where biology meets technology
Essays/linkedin/24-05-24 pitch deck is not the company
Difference between risk and uncertainty
Scipreneurs/7-day-intro/7 - moving forward
Advice
Video drop
Utrechtinc and its copy-pasting approach
Gender Diversity in Academia
Essays/linkedin/24-01-23 we are better at adding
About Aquiles Carattino
Weiwei - Agustina Luz López
Calculate the radial position of a particle in a hollow fiber
Catalytic experience of new england biolabs
Adapting Academic Skills for Business Use
Things I Want to Do
Essays/ what i wish they told me before starting the entrepreneurial path
Existing market marketing
Mitovesicles
V1 is not even remotely profitable
Choosing between Zettlr and Obsidian
Incremental change leads to unsustainable educational paradigms
Entrepreneurship for scientists
Pinephone
Private money in universities
Effects of swarm of particles in flow cytometers
Digital Garden Terms of Service
Adoption curve
Business model
Publish or perish
Xiaomei yan
Definition of OKRs
Literature/202111302113 quantifying sources of error in nanoparticle tracking analysis
The Role of Money in Open Source
The Commons
Split Writing from Editing
202201031433 RESTful API for instrument control
Why implementing OKRs
Literature/@spackova2022
Communication channels for citizen science projects
Communicators fail at explaining what an algorithm is
Egoistic scientific incentives
Effect of vibration in diffusion coefficient determination
Identifying and Validating Market Opportunities
Closing the hiring gender gap must be consequent to new performance metrics
Building Courses as Knowledge Trees
Chirality and life
Roadmaps for product development
Density gradient centrifugation
Scipreneurs don't need someone with business experience
Quadruple helix model of innovation
Psa
Selling open-hardware services
Quotes by Carl Sagan
Python for the lab public key
Preventing django from sending log emails
Particle metrix
Smile
Syntenin-1 is the most abundant protein in evs
Podcast I listened in Week 32
Swot analysis
Pareto Principle
Product requirements document
Resistive pulse sensing
Super-silac
Size exclusion chromatography
Some products are designed taking into account only men
Successful open projects are those that last longer
Reviewing Hardware Control
Product management
Spaced repetition
Spatial-based separation methods
Prakash Lab
Security services buy commercially available private data
How Does Online User Tracking Works
Prematurely open sourcing can block innovation
Neuroscientific based hiring processes
Sharing reproducible models
Essays/linkedin/24-05-21 the founder's dilemmas
The Web is built on standards
Neuromorphic detector
Inbound marketing
Nasa Risk Management System
La herida - jorge fernández díaz
Subscription Economy
Innate immune system
Open hardware projects focus on cutting costs
Installing and running Nextcloud on Raspberry Pi
Shah Selbe
Multiplex biomarker assays perform better than single cancer biomarkers
Social infrastructure
My e-mail
Essays/linkedin/24-05-10 autofluorescence
Catalytic experience of ge healthcare life sciences
Spying on people is extremely easy, still that does not make it morally correct
Essays/linkedin/24-01-03 my first entrepreneurial gig
Marketing
Limitations of nta for extracellular vesicles measurements
Low abundance evs
Market research is a commodity
Los Crímenes de la Ciudad Blanca
Substack Privacy Policy
Superlinear growth
If you are in a position of power and don't do anything, nothing will change
Hydrogels
Start with why
OpenAI release of GPT-3
Challenges with studying corrosion
Inherent violence of modern humans
How to lay out a path to create a community around a project
The problem with the power of web developers
How to present yourself in a cv
Medicine excludes women from their studies yielding biased results
Compressive raman
Hydroelectric dams are not net-zero
Value proposition
Challenges of private education projects
Historical figures under review
Como Agua para Chocolate - Laura Esquivel
The scientific risks of professors holding shares in companies
Exchange rate of scientific output
Evolution acts at an individual level
Different types of open source projects based on community engagement
Development costs of open source software
The only way to get the best of an argument is to avoid it
How to keep a lab journal
Chaos - james gleick
Evergreen Notes
Hypertext today is only a part of what it could have been
Erythrocytes
Startups
Use of hydrogels for medicine
Compress a file or directory with tar
Literature/@mazzucato2018
Literature/@laganovska2020
Scipreneurs/7-day-intro/4 - making lemonade
Business model prototypes
Literature/202405081156 impact of patent-first research approach
El cambio incremental nos puede llevar hacia lugares indeseados
Literature/202310101212 stereo darkfield interferometry
Tech notes/yarn run in docker
The abundance of tetraspanins in evs can be linked to the sample preparation protocol
Avoid unconnected warning in power poins with kicad
Literature/@ries2014
Resonance Calendar
Building and Leveraging Your Network: Engaging with Key Opinion Leaders (KOLs)
This is only a test
Talent
Self-assessment for promotions at google
Dune - frank herbert
Literature/202311240735 compressive raman for chemical reactions
Distancia de Rescate - Samanta Schweblin
Science Education
Objections to purchase
Literature/202311280944 the fake speech of free market in innovation
Literature/@lam2011
Catalytic experiences - hamid ghanadan
Science in the classroom is separated from the real world outside
Crossing the chasm
Google effect
Der Pass, German TV Show
Literature/202311281010 states are investing in lowering risks
Standardized educational tests
Not all developers are computer savvy
Science education should not distinguish disciplines
Literature/@kaufman2020
Nanosight
Self-Driving Cars
Literature/@wasserman2012
202410021554
The golden circle is a form of manipulation
{{title}}
Aquiles Carattino, Physicist, Entrepreneur, and everything in between.
Waterfall development
The Power of Building Our Tools
Literature/@bhattacharya2020
Self-Host My Newsletter
Apoptotic bodies
Cd63
Literature/@beal1956
Recycling of photovoltaic modules is challenging
Having a patent does not entail competing interests
Essays/linkedin/23-12-18 starting is hard
Structure Notes
Not all companies need to grow exponentially
Expected female traits
Pitching a startup
Okr for product management
Approximations to calculate absolute abundance of t rex
Lab Journal
Pleistocene
Reading on paper
Essays/linkedin/23-11-30 bill gates book
Finding a Problem to Solve
New market positioning
It is challenging to distinguish hiv viruses from evs
Tripe helix model of innovation
Webmentions
Openspim
Experiments for idea validation
Exposure effect
Equity for scientists starting companies
Fluorescent Labeling of Extracellular Vesicles
Essays/linkedin/24-09-19 adoption curve
Team-market fit
Encrypt and automount hard drives on linux
The world in 2050 if we commit to lowering the heating
Cd9 and cd63 are used as biomarkers in evs but they can change from cell line to cell line
Requirements of a Lab Journal
Distributed education
Earlyvangelist
Exit strategy
Segmenting a market
Streams expose us to a unique experience
Correlation between pedagogical approach and science education outputs
Cytometry
Female hunters in hunter-gatherer societies
Implementing webmentions
Applications of tracking colloids
Uncertainty in scientific exploration
scipreneurs #tto #technology-transfer #universities
Essays/linkedin/24-01-30 misconception 1 two jobs
pitching #startups #entrepreneurs
Literature/@gates2021
Device experiment view
Essays/linkedin/24-01-00 misconception 3 business experience
Why Don't we Drink Water from the Ocean?
Literature/202311101921 the biggest problem is making things
Interferometrically encoded in vivo flow cytometry
Essays/linkedin/23-12-15 fear of rejection
Literature/202303251644 jobs to be done framework
Literature Notes
Ways of delivering value
Walker algorithm
Scipreneurs/7-day-intro/6 - can you stay motivated
Why not all my e-mails are signed
Artificial intelligence is one more step in this process of automatizing
Work policies designed for the average
Literature/202103131212 aav2 capsids suffer from aggregation making them unstable and harder to use for medical applications
Literature/202303251644 ideas-first product innovation is flawed
Zeigarnik effect
Literature/202303251644 metrics used to measure success by customers
Continuity is required by persistent users
Measure the protein adsorption to MedNPs
Literature/202306121143 open hardware is not all about money
Egalitarian societies explain diveristy in hunter-gatherer groups
Literature/202311111345 net zero agriculture
Resonance calendar/eroom's law
Difference between detection and tracking of nanoparticles
Literature/202201061619 treating a business model as a scientific model
Literature/@gioria2018
Anti-zenith
Essays/linkedin/24-05-08 patents
Literature/202311281148 apple is riding the innovation wave fueled by the state
Circulating free DNA
Why would you learn how to open source projects?
Essays/there and back again 13 years apart
Literature/202301241141 separation of vesicles with free flow electrophoresis
Literature/@blank2012
Literature/202311281141 companies will invest more on applied research
Discriminating particles for tracking analysis
How ancient egyptians measured distances
Noches Milongueras
Grow your online persona with smart performative blogging
Tendering a digital garden
Nanoparticle tracking analysis
Quantifying the concentration of evs in urine or plasma through confocal microscopy
Substack Wants to Scoop as Much Information as They Can
Nanoqnt
How to take smart notes - sönke ahrens
Patents can limit the positive externalities of research products
Good design
Nanoparticle Tracking in Hollow Optical Fibers
Optical chromatography
Get the other person saying yes, yes, immediately
Model view controller
Tetraspanins are unevenly distributed across extracellular vesicles
Ten metrics to judge a market
Number of contact points in marketing
Measure the success of technology transfer from universities by using the total number of patents, licenses and spin-offs
entrepreneurship-principles
Gaussian mixture model
Linux has a package manager, why avoid it
Gender unbalance in academia
How to make more published research true
Note taking lacks internal discussions
Gardening is not just collecting
Obsidian
Essays/linkedin/24-01-29 note taking for entrepreneurs
Losing Jobs in the Hands of Artificial Intelligence
Literature/202106191120 principles of effective management
Essays/linkedin/ never stop improving
Open Hardware Business Models
Literature/@pandya2022
Light sheet spectrometry
Essays/linkedin/24-05-22 before accepting
Transclusion
Essays/linkedin/24-05-16 misconception 4 you need a lab
Damuth law
Simple explanation of an optimization algorithm
Essays/linkedin/23-12-07 the pareto principle
Literature/@scotte
The only way of improving stoves is to actually consider their main users
Low friction working
Open hardware business model
Allocation of resources in a household is not gender-neutral
What is Blockchain
Git is a poorly designed tool
De-risking technology
Video Tutorials
Adaptive immune system
Essays/linkedin/23-12-20 there are no 10 rules
Getting started with FastAPI on a Raspberry Pi
Motivation factors for scientific entrepreneurship
Connecting Basler cameras to usb hub
Gut feelings can be used to drive sales
Essays/linkedin/ what problem do you solve
Ideas are born through interaction with the world
Code Before you Think
Gamification of education
Business models for research based tools
Build - Tony Fadell
Literature/202212091127 iscat for refractive index of evs
Blood-derived evs are more challenging to study
Literature/202311281015 innovation led policies
If you are the problem, you can't be the solution
Reciprocation in sales
Heme
Guide on how to open-source projects
Hard to quantify decisions
Competitor analysis
Essays/linkedin/23-12-22 my unfair advantage
Literature/202311101858 avoiding a climate disaster
Literature/@ianuzzi2017
Reward equation
Raman emission
Reasons why scientists are not entrepreneurs
Cd81
Healthech innovation cycle
Open source
Brainstorming
§-notes
Founders need breadth over depth
Create the need for a product
Governance of Open Source
Cd9
Having sex-disaggregated data is the only way to build consistent tax policies
Replacing copper by steel made humanity less resilient to bacteria
What is a Machine Learning Algorithm
Gender biased algorithmic hiring
A demonstration is the most powerful marketing tool
Four insights of great managers
Real emissions of electric cars
Begin in a friendly way
writing #sunday-reflections
Assuming we understand the customer
Cells behave differently in the body than on rigid substrates
Literature/202211031710 characterization of physicochemical properties of nano vaccines
Resistance to the sales pitch
Essays/linkedin/24-09-17 mvp
El jardín de los senderos que se bifucan - jl borges
Linking particle positions to form trajectories
Using exosomes as drug delivery systems
Huacas
Literature notes
404
Strategyzer.com
4 p's of marketing
As we may think - vannevar bush
Words in books are like the DNA that describes our ancient history
backlinks are the core of my digital garden|backlinks
Tracking polystyrene particles
Marginal cost
Literature/202212291648 optical methods for single molecule analysis
Problems with citation-based metrics
My Wedding Website
Digital gardens for knowledge generation
Envue
Nasdaq is fundamental for quicker exits
Tracking Scripts
Essays/linkedin/24-05-23 feedback
Entrepreneruship for scientists
Scipreneurs/reasons to start a company
Analytical ultracentrifugation
Breaking the Chronological Order
Limitations of Nanoparticle Tracking Analysis (NTA)
Outsourcing experiments with open hardware tools
What is the Problem with the Single App Store Approach
Literature/202011092209 writing projects should flow associatevely and not with a top-down approach
Localization uncertainty in nta measurements
Phases of customer validation
Andy matuschak
Refeyn
The leader in you - dale carnegie
The value of code
Revisionismo de obras literarias
Las palabras en los libros son como el ADN que cuenta una historia antigua
Mixing between modern humans and neanderthals
Annotating notes
Modern monetary theory
Limitations of fluorescence for particle tracking
Tools to study in vitro toxicity of medical nanoparticles
Resourcefulness and Creativity
Siga el Baile - Orquesta Romántica Milonguera
Quantification of protein interactions and solution transport using high-density GMR sensor arrays
Stakeholders in the research publishing circle
Lower the Barrier to Writing
Understanding and Accepting the Risk of Failure
Simple rules to keep a lab journal
Essays/linkedin/ misconception 5 you need money
Async education
Applications of electrophoretic mobility
Essays/linkedin/24-03-23 ai for everything
Ampholytes
Essays/linkedin/24-04-23 competition
A New Way of Blogging
Inquiry-based science education
Can algorithms be biased
Education is not curiosity driven
Ask why
§ how i take notes of papers
Start With Why
The biases each one of us carries
This website is not a blog
Five stages of colloidal particle tracking
If you are wrong, admit it quickly and emphatically
12 dimensions of workplace strength
Cashback incentives
Writing May be the most Undervalued Skill
Concept Summary
It is not clear the amount of farming done by women
Is Github contradictory of open source values?
Essays/linkedin/23-12-01 uncertainty and risk
Importance of a prototype
Using the reward equation in education
Entrepreneurship for a pi is very different than for a phd or postdoc
Contact Me
Agile development
Correlation between brain developement and family income
Using ccd as a multiplexed sensor for biomarkers
Automount hard drive on linux
Scientific incentives push to build new not build on
Treacy-wiersema frame
Essays/linkedin/24-03-02 python for the lab book
Try honestly to see things from the other person's point of view
Science education outputs correlate with socioeconomic level
Tres Truenos, de Marina Closs
Sheri Bastien
Isotachophoresis
Maximum of shares of a company that a professor can have
Carbon capture
In spaced repetition not all tasks have the same weight
10 actions regarding climate change
5c analysis
Essays/linkedin/23-12-21 things that can scale
Incremental change can lead to undesired outcomes
Essays/linkedin/23-12-19 skills for entrepreneurs
Innovation is not the only driver for success
Web Mentions and comments for websites
Five elements that make a business
Configurable spectrometer
Essays/linkedin/24-05-14 to conference or not to conference
Schizogony
effective-writing
Education is content based
Science education is utilitaristic
Show respect for the other person's opinions. never say you're wrong
Literature/@vieillard2007
Internal analysis for new ventures
Literature/@li2022a
Instrumentation software
Ldh
Los tres incendios de la bilbioteca de alejandría
Kanban development
Tech notes/concurrent futures and threadpoolexecutor
Life cycle of the malaria parasite
Scientists are shifting their attention from traditional to social media
The web does not resemble the memex
Literature/@merryweather2022
Literature/202404021200 free flow electrophoresis for plasma processing
Separating evs based on density
Scipreneurs/7-day-intro/0 - welcome message
Literature/@boccara2016
Interruption marketing
Literature/202404021206 integrated waveguide on electrophoretic separation
The myth of the double blind
Using the Python walrus operator
Scientific collaboration yields better outputs than scientific competition
Knowledge is a positive externality
Size exclusion chromatography is the second most popular ev enrichment method
Tech notes/pykka and the actor model
Literature/@libregts2018
Rpg for teachinig
Sleeping Giants - Sylvain Neuvel
Carbon Tax
Professors can lead to the first sale
Leukemia and lymphoma
Startups search for business models
Creating .desktop files
Literature/@cagan2018
Literature/202310101226 tracking magnetic beads in 3d
Product vision and product strategy
Structure of a digital garden
Literature/@chesbrough
Tech notes/windows 11 bootable on a mac
Literature/202311111357 emissions from moving around
How to Remember how to Link notes in a Digital Garden
202404281926
The Scipreneur Playbook
Phenotype
Setup Wacom Tablet in Ubuntu
How I built this website using Python and Markdown
Innovation leads to growth
Writing down as a mean to understanding what we read
Blue ocean strategy gives little insight
Genetically modifying humans for space travel
Scientific publishing is the largest experiment on backlinking we have access to
Science after wwii has stagnated
Holocene
Phases of customer discovery
Open hardware should not be a strategy to overcome licensing
Effective feedback gathering
Essays/linkedin/24-01-04 incomplete ideas
Founders must lead customer validation
Lifecycle of a sicentific idea
Minimum viable product
Depletion of the low-hanging fruit in science
Error handling in python
Cramming is not understanding
Nitrogen problem
Eggs in argentinian shores are from a snail
Open source checklist before publishing a paper
NanoCET Implementation
How Can a Newsletter Track You
Multitasking does not increase productivity
Privacy Policy
Problem with single-objective lightsheet
Learning in Public
Paternity leave
Product vision
Elisa test
Features are not benefits
Flow cytometry
Fluorescence arising from dye aggregates
Entrepreneurial lemonade
Measure the exploration factor of research
Pareto Principle (Mental Model)
Origin of the term digital garden
Why pushing sensitivity of assays
Images/mentor
Specific value in being open hardware
Octopi, Open (?) microscope able to process 1.5M red blood cells/min
After a Failure, Revert to the Last Known Working State
Ovsiankina effect
Proteomeic profile of evs
Pivot-or-proceed
Cell-mediated immunity
Patents and researchers
Sources of error in measuring diffusion coefficient through nanoparticle tracking analysis
Plurality of online spaces
Essays/linkedin/23-12-14 think like a designer
Phones were designed to spy on us
Customer interviews
Comments on Digital Gardens
Remember that a person's name is to that person the sweetest and most important sound in any language
Specialty parts suppliers for open-hardware tools
Optimal track length for msd measurements
About this Website
Curiosity-driven education
Science education could focus on understanding the world around people
Blue ocean strategy
Why I stopped using Facebook
Titles of notes are fundamental
The Liberation of RNA (podcast)
Backlinks are the Core of my Digital Garden
Essays/linkedin/24-04-22 becoming a technologist
The Neanderthal in Us
Ephemeral Notes
Scipreneurs/7-day-intro/3 - find out what do you need
Erenna
Repensando el rol de la tecnología en la educación
Actor model
Tunable resistive pulse sensing
Design process
Zero-mode waveguide
Using slots in your classes to prevent attribute creation at runtime
Aufhebung
Literature/202310112003 acoustic force spectroscopy for single-molecule applications
better thinking
User experience
Dictionary Views in Python
Refining the position of nanoparticles on an image
There is always a solution to the problem
Primary education to establish the basis of scientific thinking
Essays/linkedin/23-12-08 onboarding early employees
Catalytic experiences
Bikepacking
Literature/202304141533 learning environments foster diversity
Be sympathetic with the other person's ideas and desires
Federated wiki
Role of introgression to define the percentage of modern and neanderthal genome
Literature/202311240722 compressive raman with spad arrays
Democratic systems do not guarantee gender equality
Gender bias in scientists can build the wrong knowledge over generations
Do Things That don't Scale
incubators #equity #startups #entrepreneurs
Literature/202311111406 policies for a net zero future
Efficient iteration
Using scattering instead of fluorescence
Podcast I listened in Week 36
Luhmann notes are static
Customer development
Essays/linkedin/23-12-12 business readiness
What happens when notes become long
El secreto de Antoni
Increase the number of frames for tracking by confining the movement of a nanpoarticle
The fallacy of the carbon emitters
The hidden power of individual reviewers
Essays/linkedin/24-05-03 why i write online
Citizen science can bridge the gap between school science and the real world
Starting a company is like jumping off a cliff and assembling a plane on the way down
Funding Your Venture: Grants, Investors, and Beyond
Low friction working
Essays/linkedin/24-05-01 getting started
Catalytic experience of biotix
Dispertech e-mail public key
Quantifying performance using multiple measurements
La ciencia ciudadana recupera el rol de la observación de la naturaleza
Backlinks
Solving or Removing problems
Literature/@dent2006
Literature/202405081113 against research exemptions
Literature/202212291643 errors in amino acid sequences
Leveraging the digital medium for better note taking
Literature/202210011658 the five dysfunctions of a team
Hipster hacker hustler
Flow induced dispersion analysis
Multiparametric Optimization Problem
Literature/202306221512 sers to identify cancer evs
Essays/professors can enable scipreneurs
Swarming
Maintenance costs of open source projects
Return of Oñate's Foot (Podcast)
The garden or the stream
Exporting the idea of the free market for innovation
Literature/@teixeira2016
Essays/my story as a founder
Eratosthenes measurement of the circumference of the earth
Work in progress
Notes on "How to take Smart Notes" by Sönke Ahrens
Effective interventions to make more published research true
Ev targeting
scipreneurs #scientists-entrepreneurs #market-size
Taking notes for writing products
Make decisions with incomplete information
Hiv-1 contains cd9 and cd63
Literature/@meyvis2021
How to Build Links Between Notes
202201031452 Tiny Instrument Element
Literature/202206291350 biomolecules scattering inside nanochannels
Literature/202106010813 affordable loss for entrepreneurs
Lowering the Maintenance burden of open source projects
My phd
Literature/202303251644 needs-first product innovation is flawed
Scipreneurs/7-day-intro/5 - was that a good idea
Evs can be used as ovarian cancer markers
Github Actions
Essays/linkedin/23-12-17 sexism in academia
202409160819
Literature/202410012123 product strategy
202306121208
Ev labeling methods and cautions learned from flow cytometric analysis of single evs by xiaomei yan
Scipreneurs
Literature/@kapanidis2016
Literature/202212301234 biggest challenge of single-molecule methods is non-specific binding
Product market fit with biased data
Nieve de primavera - Mishima
Ev isolation and purification
Four stages of competence
Learning Javascript
Don't criticize, condemn, or complain
Teaching curricula in latin america fail to guide teachers
Brilliance bias
Science education should be method-oriented
Literature/202405081119 in favor of research exemptions
202405070914
To tweet
Mentor, Consultant, Coach, Partner: Who Do You Need Right Now?
Product-market fit
The Uberization of the Workforce
Hiring a copy editor for python for the lab
Talk in terms of the other person's interests
Evs that inhibit viral infection
Literature/@barbabazan2021
Give honest and sincere appreciation
Become an expert by practicing
Dunning-kruger effect
Design Rules for OKRs
Evolution must be selfish
GAFA CEO's testify in front of the US Congress
Challenges of electrophoretic mobility measurements
Are rewards useful to build a habit
Indecision freeze
Premature scaling can limit system iteration
EV
Extractive contributions to open source projects
Not all hominins drove extinctions in islands
Externality in economics
Customer journey and touchpoints
Essays/ skill building
Teachers bring their own knowledge gaps to the classrooms
Klara and the Sun - Ishiguro
Notes should be concept-based
Public engagement with research activities
Novelty is not Innovation
Tango in Times of Corona
Why we teach science in school
Essays/linkedin/24-05-15 marketing for scipreneurs
The effect of the track length on the accuracy of the diffusion coefficient in MSD measurements
Hydrogels can encapsulate live cells
Literature/@pedrioli2021
Limitations of flow cytometry
How to Make Cool Underlines for Links with TailwindCSS
Gardening in public
Comparing facebook revenue with country budgets
City planning with biased data
Literature/202301241150 different modes of operation of microfluidic free-flow electrophoresis
Genetic studies reveal relationship between different homo species
Education allows upwards social mobility
Spectradyne
Mental Model
Executives are not effectual reasoners
Reversing Science Education
Arctoris Lab Automation
Scientific products
Literature/open-source miniature spectrophotometer (osms)
Founders have a fundamental role in customer discovery
Marketing blogs are not meant to be a digital garden
Gender neutral infrastructure favors men
My Wedding App
Non-egalitarian groups reside with fewer unrelated individuals
Philips Monitors Make an Annoying Sound
Extracellular vesicles as markers for prostate cancer
Measuring size of evs with confocal microscopy
Klimaat helpdesk
How can links replace the ordering of notes in a box
Eccentric scientist type
Let the other person feel that the idea is his or hers
Men overestimate their smartness
Kano model
Technology readiness level
How much unpaid work is done by women
Unpaid work done by women
Ultra centrifugation
Everyone can Build a Twitter Audience
Mendeley
Aquiles Carattino Open Notes
Scipreneurs need someone with whom to build
Fundamental Attribution Error
How to write a good cover letter for a job
Tasks to write efficiently
Cartesian dualism
Product development
Throw down a challenge
Python for the Lab
Venture capitalists
Dewey decimal classification
Essays/linkedin/23-12-13 trust for startups
Stimulated raman emission
Building complexity by linking articles
Sp-iris
Violencia, boliches, rugby y las cosas que nadie discute
Scientific exploration and play
How to write a programming book
Sócrates estaba en contra de los libros
Proton Mail takes a Stance Against Apple Practices
Digital gardens for content creation
Problem recognition
Luhmann notes are static
Deep tech
scipreneurs #scientists-entrepreneurs #equity
Effect of temperature on determination of error in diffusion measurements
Scientist are changing how they consume content
Spin sales
Early progress is not a persistent indicator
Building reputation
Citizen science
Exoview
Brownian Diffusion
Personal data collection, what is it and where it starts
Dispertech
Essays/linkedin/24-01-25 kings or rich
Being Wrong in Public
Patents and Research
Evs and viruses are similar
Product market fit for scientific instrumentation
Ciencia ciudadana
failing #startups #entrepreneurs
RSS Feeds in Digital Gardens
Essays/how it feels quitting your own startup
Product lifecycle
Patents can be used to block third parties
Catalytic experience of invitae
The problem with people in positions of power in academia
Tech Notes
Bias towards men problems means less research focused on women health
What are patents for
Post hoc ergo propter hoc
Bikepacking trip through Belgium
The sociology of lockdowns
Carbon Cycle
Negative 2000 lines of code
Sec
Calculating diffusion coefficient from jump statistics
Luhmann method
Value proposition-market fit
The 3-month scipreneurial path
Essays/linkedin/24-01-11 build tony fadell
Simoa
Open Source is not what it was
Designing tools for work is traditionally done considering the *average* man and not woman
The Eleventh Commandment - Jeffrey Archer
Parsing tags in markdown
Education content for sales
Bayh-dole act to favor commercialization of university technology
Correlating gdp to scientific productivity is a reasonable proxy for progress
Social mobility
Literature/202304141541 diversity efforts that work
Essays/linkedin/ crossing boundaries
Sobre Aquiles Carattino
Company building
Categories of competitors
The Passion Economy
Technolgy transfer
Circulating tumor cells
Value-based selling
Technology push
Citizen science can create a more participative democracy
El tango de la guardia vieja - arturo pérez-reverte
Humoral immunity
Ultra centrifugations is the most popular ev enrichment method
Reforestation
Dramatize your ideas
Hplc
Role of regulatory bodies in the gender data gap
Basic competences that define scientific literacy
University students perform poorly in basic science tests
Social networks exploit the reward equation
Why footnotes should be side notes on websites
Scientific instruments
We are Craving for Data
Tyranny of the langmuir binding isotherm
Science-based startups
Changing scientific incentives can help overcome stagnation
Quantitative performance measurements produce undesired outputs
Since most startups fail, there's a large number of false positive observations
Calculating the gdp of a country should include the unpaid work done by women
A Healthier Internet
Patents
Open science
Why keeping a lab journal
Overload of information is pushing us to spaces with restricted access
Optimal number of fitting points for msd measurements
Risk
Zotero
Social media for scientific marketing
Overkill hypothesis
The Economy of Open Source Software
Advise
Science only works in the Class Room
Limits of time-based separation methods
Siloing of Information
Why improving the science teaching
Prostate cancer
Patents and spin-offs do not have the same added value
Taking notes for knowledge creation
Subscription-Based Product
Startups are not scaled down versions of companies
Switching contexts has a cost
Limitations to A4F-DLS-MALS
Scipreneurs/book/00 index
Effectual bird in the hand
Neanderthal dna deserts
Molecular shot noise
Nanoscale deterministic lateral-displacement pillar arrays
Essays/linkedin/24-05-13 startup studio for deep tech
Essays/linkedin/24-04-30 too busy for your team
Literature/202111292230 diesel is the most efficient energy storage solution for transport
202304011243
My public keys
Talk to Me
Motivations for entrepreneurs
Project hail mary - andy weir
Nanoview biosciences
The traditional marketing funnel
Essays/linkedin/ reality
Mtt
Flux biosciences
Identifying the biggest solutions
Measuring
Essays/linkedin/24-05-17 label free
Literature/@gentner2023
Exosomes
Literature/202405110829 cytometer to measure full empty ratio of lnp
Limitations of fluorescence labeling for quantification
Essays/linkedin/24-05-06 six sigma
Literature/202405081109 patents in research institutions
The role of a distributor
Literature/202301141333 comparing simoa and sp-iris
Market requests for a technology
Essays/linkedin/24-05-28 average advice
Expansion microscopy
Literature/202306121207 using open-hardware to bypass ttos
{{title}}
How the scientific mind works
Things i try to increase diversity
Developing an Entrepreneurial Mindset
Trps
Gross margins
Machine learning
Launching and Scaling Your Startup: Strategies for Growth and Sustainability
Money incentives to build a community
NSM
Literature/202212281528 refractive index measurement of evs with inta
Measuring performance using single criteria
Essays/linkedin/ brainstorming
Hermeneutic circle
Technology Transfer
High value ideas are based on research and science
Modeling Data as a Scarce Resource
Maternity leave
Making Myself Available for a Talk
Entrepreneurial Mindset for Scientists
Process of Automatizing
Literature/@rieu2021
Innovation led policies
Literature/202306121138 different types of open hardware
Male by default
Determining drug loading and release kinetics in nanoparticles
Imaging flow cytometer
Substack
Essays/linkedin/ open innovation
My Writing Habits
Literature/202101311220 a new ontology to understand inca cosmology
Tr-fia
Literature/@scotte2020
Gender Unbalance
Literature/202311221425 - skills to become a scientist entrepreneur
Literature/202405081203 open-source model for patents
Make the other person feel important - and do it sincerely
Essays/linkedin/24-03-28 outside the box
What Is a Blogchain?
Technological progress is slower than Moore’s law predicts
Essays/linkedin/24-02-06 misconception 2 equity split
Open hardware microscope chambers
Cogs
Even if correlation is not causation
Playbook Entrepreneurship for Academics
Teachers lack tools to design a science curriculum
Columbus could have used a wrong estimate of earth's diameter
Sales roadmap
202206290743
Astroplant
Essays/linkedin/24-04-24 capital costs deep tech
Why doing a phd
innovation #productdevelopment #productmarketfit
Open hardware
Piloting a new venture
Operación Kazán - Vicente Vallés
Bullet journaling
Composite measures of performance
Why companies fund open source software
scipreneurs #startups #innovation #scientists-entrepreneurs
Essays/linkedin/ overvalue gray hair
Improved methods for fluorescent labeling and detection of single extracellular vesicles using nanoparticle tracking analysis
Mentorship is an invaluable asset for starting entrepreneurs.
Determining the best number of fitting points for MSD data
Online version of Python for the Lab
Retrieval and storage strength
Notes on Working in Public - Nadia Eghbal
Nta
Digital gardens and personal blogs
RSS Feed
We think future is something that happens to us
La Inevitabilidad de Envejecer
Essays/linkedin/23-12-05 co founders
Essays/linkedin/24-01-10 ai for everything
Replacing analysis with statistics
Role Models
Choosing between Zettlr and Obsidian
Design thinking for business models
Reproducibility is the key factor of open science
Restrictions can help the creative process
Content centric model of marketing
Balliamo - Orquesta Típica Andariega
Uncover the desire
Syntenin-1
scipreneurs #productmarketfit #customeroriented
Intellectual Property and Protecting Your Innovations
Calculating diffusion coefficient from mean squared displacement data
Formatting strings in two steps with Python
Una extinción dentro nuestro
Essays/linkedin/24-01-09 making it cheaper
Washburn's Equation
Hollow core fibers can increase the throughput of analyzed particles
Open innovation
Las máquinas no pueden soñar
Limit the number of male speakers in conferences
Resegmented existing market positioning
Literature/202410012120 product vision
Me-lead vc firms are biased towards favoring men-specific problems
The Price of the Amazon Rainforest
Aquiles.me newsletter
Minimum viable prototype
If a person is exposed to a figure for 500ms they'll be able to remember some features and draw conclusions
Scipreneurs/7-day-intro/2 - find out what you do
Now
Iscat
Single-molecule detection with a 3d printed microscope
Free flow electrophoresis
Mass spectrometry
Literature/@kim2015
How to extract ev's from blood plasma
Hype curve
Embracing the Scipreneur Mindset: Transitioning from Scientist to Entrepreneur
Net margins
Hollow optical fibers
Nanoparticles
Market type
Mbfcm
Epitope
Epistemic Status
Flow cytometer
Literature/202311280851 tracking charges in lithium electrodes
Illumion
Hollow optical fiber
Extending USB cable with Amphenol connector
The status quo of the research industry
I don't think blogs broke the internet
How Technology can Shape Education
Locating particles for nanoparticle tracking
I deleted my Facebook account
Knowledge spill-over
202405221743
Inca Cosmology
Hollow core fibers
Let the other person do a great deal of the talking
Technology not addressing a problem
Nanosight proprietary software update
202304271736
The three worlds of the andean cosmos
Bioenergy with Carbon Capture and Storage
Startup studio
How phillips protected ip by not outsourcing key manufacturing components
Adding a .env file to vscode so it finds our python module
The Community Around Open Source
Random forest particle classifier
Levels of awareness for marketing
Zettelkasten method
Democracy and algorithms
Epigenetics
Cumulative culture
Functional or Imperative Programming
Inflation
Risks and opportunities of open-source are misjudged
There is a discrepancy in the reported concentration between nta and evquant
Citizen science in schools
Sales are based on trust
It's a pity that RSS feeds are fading away
Challenges for the use of hydrogels in medicine
Data collection
Scrum development
Facebook Can't Regulate Itself
Isoelectric focusing
Differential schemes for particle detection
Hiring based on talent
Bomboncito de Napalm
Extracellular vesicles
Love the problem if you don't know what it is
Effectuation theory for entrepreneurs
Inta
Build trust in a team
Establishing thresholds for idea validation
Sporozoites
Essays/linkedin/ startup team
Habits are persistent
Izon
Images/screenshot
scipreneurs #entrepreneurs #startups #superlineargrowth
Los romanos adoptaron la cultura griega
We Missed the Opportunity to Make the Right Choice and Build a Better Internet
Jobs theory around scientific products
Essays/linkedin/ misconception 6 de risking
Dark forest theory
Classification systems are crucial for a language survival
The role of search engines for scientific marketing
Myriade
Essays/ splitting shares of a startup should reflect future work
Become genuinely interested in other people
Dark, german TV Show
Customer discovery
Risks in starting a scientific company
Develop a combination of methods to measure particle size distribution of medical nanoparticles
Gray hair fallacy
Slow Horses - Mick Herron
First-mover advantage
Crazy quilt around a product
Literature/@bloom2020
The interaction between Stackoverflow and Github
Common problems with open source projects
The power of flow cytometry
Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
Pricing products
Freeing short term memory
Coulter counter
Essays/linkedin/ misconception 7 you need a ceo
Customer validation
Reactivating past customers
shinrin-yoku
Ccmv virions
Selling open-hardware tools
Be a good listener. encourage others to talk about themselves
La forma de leer cambió en el tiempo
Public engagement with research is challenging
Women are half the population, not a minority
The five different types of attention when doing creative work
Difference conda environment and virtual environment in pyhon
Is openspim a good example of open hardware
Image restoration for nanoparticle tracking
Poisson sampling
Business model canvas
To pay or not to pay reviewers of scientific papers
Mbti personality indicator
Grant recipients are ageing
Literature/202311280955 socialize risks and privatize rewards
Job titles can stunt startup development
Essays/linkedin/23-12-11 science needs entrepreneurship
Gender diversity in tech
Multiplex bead-based flow cytometry
3r principle
Get Time of First Commit of a File
Stokes-einstein relationship
Disadvantage of hollow optical fibers for exciting particles
Digital Garden
Digital garden
Time-based separation methods
Venture capital is more short-termist than what research needs
Correletion between time spent and competency in scientific literacy
Literature/202311111404 staying warm and cool
Essays/the things i miss the most from my time as a phd
Essays/linkedin/23-12-06 working hard
Calibration services for open-hardware tools
Essays/linkedin/23-11-16 male deep tech

Comment

Share your thoughts on this note. Comments are not public, they are messages sent directly to my inbox.
Aquiles Carattino
Aquiles Carattino
This note you are reading is part of my digital garden. Follow the links to learn more, and remember that these notes evolve over time. After all, this website is not a blog.
© 2024 Aquiles Carattino
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License
Privacy Policy